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  • Protamine zinc (PZI) insulin (brand name Prozinc®) is an injectable medication approved for use in cats and dogs with diabetes mellitus. It is used to lower blood sugar levels and for long-term maintenance therapy of diabetes mellitus. This medication may be used “off label” or “extra label” in other species. Monitor closely for signs of low blood sugar (weakness, lack of energy, lethargy, stumbling or difficulty walking, behavior changes, muscle twitching, seizures, and/or unresponsiveness).

  • Interferon alfa is given by mouth or injection and is used off label to treat certain viral diseases in dogs and cats. Give as directed by your veterinarian. Side effects are uncommon but may include vomiting or decreased appetite. Do not use in pets that are allergic to it or that are receiving immediate vaccination. If a negative reaction occurs, please call your veterinary office.

  • This handout outlines common internal parasites in cats. Included are parasites of the gastrointestinal tract (roundworms, hookworms, and tapeworms), as well as parasites of the circulatory system (heartworms). How each of these parasites can affect your cat and what you can do to prevent or treat infection are explained.

  • Intestinal tumors are uncommon in dogs and cats, comprising about 2% of all cancers. There are many kinds, including leiomyosarcomas, lymphomas, adenocarcinomas, mast cell tumors, gastrointestinal stromal tumors (GISTs), plasmacytomas, carcinoids, and osteosarcomas (all malignant) and leiomyomas, adenomatous polyps, and adenomas (all benign). Most intestinal tumors are malignant. Intestinal tumors are more prevalent in older animals and certain breeds. Signs, diagnosis, and treatment are discussed.

  • In some cases, two laid-back adult cats can be easily introduced with minimal drama. In other cases, however, the introduction does not go as smoothly. Some adult cats may physically fight with each other, resulting in potential injuries. Even in the absence of physical aggression, introductions can provoke anxiety that leads to inappropriate elimination, decreased appetite, or other signs of stress in one or both cats. Fortunately, you can help increase the likelihood of success by introducing two adult cats slowly and gradually.

  • Using desensitization and counterconditioning, a behavior modification technique, can change a pet's negative emotional response to triggers. The technique is well suited for pets experiencing fear, frustration, or hyperarousal. Desensitization must be done slowly and systematically to avoid inadvertently sensitizing the pet.

  • Isoflupredone combinations topical are combination medications containing isoflupredone (a corticosteroid) and other medications. Isoflupredone may be compounded with an antibiotic, a local anesthetic, or other medications to treat surface skin conditions where use of a steroid combination product is indicated. Its use may off label (extra label) depending on the species, condition(s) being treated, and formulation. Isoflupredone combinations topical come in powder and ointment forms, often specially compounded.

  • Itraconazole is given by mouth in the form of a capsule, tablet, or liquid to treat fungal infections in cats and for off-label treatment in dogs and small mammals. The most common side effects are anorexia, vomiting, liver toxicity, skin lesions, or limb and vessel swelling. It should not be used in pets with liver disease or low stomach acid production, and used with caution in pregnant, lactating, or pets with heart disease.

  • Ivermectin is most used as a heartworm preventive in dogs and cats. It is also used off label for treating a variety of internal and external parasites. Ivermectin may be combined with other deworming medications. Ivermectin is available as tablets, chewable tablets, a topical liquid (for ear mite treatments), and an injectable that your veterinarian will administer.

  • A joint luxation is a dislocation or complete separation between the bones that normally move back and forth to form a joint. Subluxation refers to a partial separation of the joint. The most commonly subluxated joint in cats is the hip, although any joint can be affected. Your veterinarian may suspect a joint subluxation based on a history of trauma and physical examination findings such as pain and limping. A radiograph is necessary to definitively diagnose a joint subluxation. In many cases, the joint can be reduced or replaced to its original orientation by a procedure called a closed reduction, with a good prognosis if treated immediately. Surgery correction, however, may be needed.